Direct effects of an opioid peptide selective for μ-receptors: intracellular recordings in the paraventricular and supraoptic nuclei of the guinea-pig
JP Wuarin, FE Dudek - Neuroscience, 1990 - Elsevier
Abstract Responses to [d-Ala 2, MePhe 4, Gly-ol 5] enkephalin, a selective agonist for μ-
receptors, were recorded intracellularly from 26 neurons in slices of guinea-pig
hypothalamus. Of eight cells tested in the supraoptic nucleus, all of which had electrical
properties characteristic of magnocellular neuroendocrine cells, four were sensitive to the
agonist applied in the perfusion bath or with microdrops. The main effect was a decrease or
suppression of spontaneous firing. In the paraventricular nucleus, seven of 18 cells tested …
receptors, were recorded intracellularly from 26 neurons in slices of guinea-pig
hypothalamus. Of eight cells tested in the supraoptic nucleus, all of which had electrical
properties characteristic of magnocellular neuroendocrine cells, four were sensitive to the
agonist applied in the perfusion bath or with microdrops. The main effect was a decrease or
suppression of spontaneous firing. In the paraventricular nucleus, seven of 18 cells tested …
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